Ribose phosphate biosynthetic process

Across TCGA cell cohorts, RNA activity of the Ribose phosphate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP5F1B, RPL41, and PPTC7, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribose phosphate biosynthetic process activity versus ATP5F1B in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	ATP5F1B →	+1.092	+0.332	<.001	<.001	3	7
LIVER	RPL41 →	+0.898	+0.253	<.001	.009	3	5
OVARY	PPTC7 →	+0.664	+0.155	.004	.009	2	6
PANCREAS	KIAA0100 →	+0.779	+0.277	.004	.009	3	5
STOMACH	UBALD1 →	+1.024	+0.197	.004	.007	2	6
BREAST	ITGB1 →	-1.179	-0.167	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046390 vs ATP5F1B — UPPER_AERODIGESTIVE_TRACT

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