Regulation of glucose import

Across TCGA patient cohorts, RNA activity of the Regulation of glucose import pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FTX, NPTN-IT1, and ZFC3H1, each associated with the pathway in up to 31 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of glucose import activity versus FTX in THYM (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	FTX →	+0.786	+0.048	<.001	<.001	3	31
SARC	NPTN-IT1 →	+0.904	+0.034	<.001	<.001	3	30
UVM	ZFC3H1 →	+1.144	+0.039	<.001	<.001	3	29
TGCT	AGO4 →	+0.915	+0.027	<.001	<.001	3	29
KICH	DMXL1 →	+1.179	+0.030	.001	<.001	3	29
THYM	MIR186 →	+2.212	+0.050	<.001	<.001	3	29

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046324 vs FTX — THYM

Explore this scatter interactively →