Regulation of fatty acid oxidation

Across TCGA cell cohorts, RNA activity of the Regulation of fatty acid oxidation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CPT1A, TANGO2, and MCM7, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of fatty acid oxidation activity versus CPT1A in LUNG_SCLC (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CPT1A →	+1.753	+0.905	.002	.005	3	9
LUNG_SCLC	TANGO2 →	+0.699	+0.926	.001	.008	3	5
BLOOD_Leukemia	MCM7 →	-0.690	-0.880	.003	.003	3	4
PANCREAS	CCDC115 →	+0.585	+0.451	.006	.007	3	4
LARGE_INTESTINE	NIPAL2 →	+1.109	+0.653	.009	.004	3	4
LARGE_INTESTINE	TIMM23 →	-0.592	-0.768	.006	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046320 vs CPT1A — LUNG_SCLC

Explore this scatter interactively →