Aldehyde catabolic process

Across TCGA patient cohorts, RNA activity of the Aldehyde catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NMD3, HMGN2P30, and SPINDOC, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aldehyde catabolic process activity versus NMD3 in UCEC (Pearson r = -0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NMD3 →	-0.552	-0.132	<.001	.001	3	4
OV	HMGN2P30 →	-0.462	-0.125	<.001	<.001	3	4
LSCC	SPINDOC →	-0.462	-0.167	.004	.003	3	4
LSCC	PAICS →	-0.524	-0.138	.002	.004	3	3
LSCC	NRM →	-0.520	-0.174	<.001	.002	3	3
LSCC	POLE3 →	-0.735	-0.215	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046185 vs NMD3 — UCEC

Explore this scatter interactively →