Alcohol catabolic process

Across TCGA patient cohorts, RNA activity of the Alcohol catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AKR1C3, DHRS3, and ALDH2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Alcohol catabolic process activity versus AKR1C3 in UCEC (Pearson r = 0.50).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AKR1C3 →	+1.108	+0.070	<.001	<.001	3	7
UCEC	DHRS3 →	+0.889	+0.090	<.001	<.001	3	6
BRCA	ALDH2 →	+0.517	+0.037	<.001	<.001	3	6
CCRCC	ANK3_S916 →	+0.519	+0.031	<.001	<.001	3	6
PDAC	CMBL →	+0.428	+0.037	<.001	.001	3	6
GBM	SQOR →	+0.483	+0.039	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046164 vs AKR1C3 — UCEC

Explore this scatter interactively →