Alcohol catabolic process

Across TCGA cell cohorts, RNA activity of the Alcohol catabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUDT3, SULT2A1, and ALDH3B1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NUDT3 grouped by Alcohol catabolic process-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	NUDT3 →	-0.170	-0.939	.009	.001	3	4
CNS	SULT2A1 →	-0.133	-0.565	.005	.009	3	4
SOFT_TISSUE	ALDH3B1 →	-0.215	-1.070	.004	.002	3	4
SOFT_TISSUE	ADH4 →	-0.333	-0.947	.001	<.001	3	4
LARGE_INTESTINE	HNRNPC →	-0.290	-0.934	.003	<.001	3	4
KIDNEY	DUOX2 →	-0.220	-1.059	.004	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NUDT3 by Alcohol catabolic process activity — SKIN

Explore this box plot interactively →