Alcohol catabolic process

Across TCGA cell cohorts, RNA activity of the Alcohol catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BDNF, GCLC, and ALDH2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Alcohol catabolic process activity versus BDNF in OVARY (Pearson r = -0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	BDNF →	-2.213	-0.246	<.001	.002	3	6
LUNG_NSCLC_LUAD	GCLC →	+1.456	+0.382	.001	.001	3	5
LUNG_NSCLC_LUAD	ALDH2 →	+2.588	+0.436	<.001	<.001	3	5
LARGE_INTESTINE	TWSG1 →	-1.176	-0.264	.009	.005	3	5
KIDNEY	TSKU →	+2.532	+0.499	.008	.007	3	5
LUNG_SCLC	RNF43 →	+1.675	+0.200	.001	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046164 vs BDNF — OVARY

Explore this scatter interactively →