Nucleobase biosynthetic process

Across TCGA patient cohorts, RNA activity of the Nucleobase biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SETDB1_S1066, TOP2A_S1247, and XPO5, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleobase biosynthetic process activity versus SETDB1_S1066 in UCEC (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SETDB1_S1066 →	+0.895	+0.065	<.001	.004	3	8
UCEC	TOP2A_S1247 →	+0.897	+0.080	.002	.008	3	8
LSCC	XPO5 →	+0.523	+0.065	<.001	<.001	3	8
UCEC	RFC3 →	+0.305	+0.085	<.001	<.001	3	7
BRCA	RIF1_S2393 →	+0.663	+0.043	<.001	<.001	3	7
BRCA	RIF1_S782 →	+0.881	+0.042	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046112 vs SETDB1_S1066 — UCEC

Explore this scatter interactively →