DTMP metabolic process

Across TCGA patient cohorts, RNA activity of the DTMP metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC4, RFC2, and RRM2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DTMP metabolic process activity versus SMC4 in BRCA (Pearson r = 0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SMC4 →	+0.450	+0.051	<.001	<.001	3	9
HNSC	RFC2 →	+0.380	+0.094	<.001	<.001	3	8
UCEC	RRM2 →	+0.658	+0.109	.002	<.001	3	8
LSCC	UHRF1 →	+0.631	+0.077	<.001	<.001	3	8
BRCA	MCM4 →	+0.754	+0.066	<.001	<.001	3	8
BRCA	MCM5 →	+0.729	+0.069	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046073 vs SMC4 — BRCA

Explore this scatter interactively →