DTMP metabolic process

Across TCGA patient cohorts, RNA activity of the DTMP metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UPP1, HMMR-AS1, and ZBTB7B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DTMP metabolic process activity versus UPP1 in HNSC (Pearson r = 0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	UPP1 →	+1.012	+0.141	.007	<.001	3	6
CCRCC	HMMR-AS1 →	+0.159	+0.181	<.001	<.001	3	5
PDAC	ZBTB7B →	-0.346	-0.104	<.001	.001	3	5
OV	ENPP5 →	-0.716	-0.151	.007	.005	3	4
CCRCC	CRY2 →	-0.630	-0.146	<.001	<.001	2	5
CCRCC	NEIL1 →	-0.639	-0.144	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046073 vs UPP1 — HNSC

Explore this scatter interactively →