ADP metabolic process

Across TCGA patient cohorts, RNA activity of the ADP metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CGRRF1, PPM1A, and XG, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, ADP metabolic process activity versus CGRRF1 in BRCA (Pearson r = 0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CGRRF1 →	+0.527	+0.189	.001	<.001	3	4
GBM	PPM1A →	+0.372	+0.138	.008	.004	3	4
UCEC	XG →	+1.124	+0.082	.007	.009	3	4
BRCA	ADRA2A →	+0.990	+0.138	<.001	<.001	3	4
CCRCC	RNU6-623P →	+0.741	+0.199	.001	.003	3	4
BRCA	CCDC126 →	+0.800	+0.191	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046031 vs CGRRF1 — BRCA

Explore this scatter interactively →