ADP metabolic process

Across TCGA pan-cancer cohorts, RNA activity of the ADP metabolic process pathway is associated with patient survival in 18 of 34 cancer lineages. Pathway activity is summarized from the expression of its 8 member genes.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ADP metabolic process pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as THCA and READ, show the opposite pattern, with higher activity associated with better survival.

HNSC, LUSC, and THCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.583	0.726	<.001	136	view →
LUSC	DFS	Tertile	All	0.689	0.823	<.001	79	view →
THCA	OS	Median	II,III,IV	1.000	0.327	.002	55	view →
ACC	OS	Quartile	II,III,IV	0.675	1.000	.005	35	view →
KICH	DFS	Median	All	0.551	1.000	<.001	21	view →
UCS	OS	Tertile	II,III,IV	0.451	0.724	.036	18	view →
READ	DFS	Tertile	All	0.906	0.448	.011	15	view →
LIHC	OS	Tertile	II,III,IV	0.303	0.643	<.001	13	view →
THYM	OS	Tertile	II,III,IV	0.835	1.000	.005	9	view →
COAD	DFS	Tertile	III,IV	0.532	0.259	.041	7	view →
PAAD	OS	Tertile	III,IV	0.723	1.000	.045	6	view →
CHOL	DFS	Quartile	All	0.174	0.811	.010	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

GO:0046031–HNSC (DFS)

Open the HNSC breakdown →