ADP metabolic process

Across TCGA cell cohorts, RNA activity of the ADP metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TARBP1, MGAT4B, and AMDHD2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TARBP1 grouped by ADP metabolic process-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	TARBP1 →	-1.280	-0.426	.001	<.001	3	5
SKIN	MGAT4B →	-0.313	-0.431	.003	.009	3	5
BREAST	AMDHD2 →	-0.931	-0.253	.003	.007	2	6
LUNG_NSCLC_LUAD	CLCN7 →	-1.003	-0.596	<.001	.002	3	5
STOMACH	C2orf72 →	-2.271	-0.217	.006	.002	3	5
STOMACH	HMBOX1 →	-0.705	-0.162	.003	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TARBP1 by ADP metabolic process activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →