Regulation of transcription by glucose

Across TCGA cell cohorts, RNA activity of the Regulation of transcription by glucose pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARL14EP, MCEE, and SH3PXD2A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of transcription by glucose activity versus ARL14EP in BLOOD_Leukemia (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ARL14EP →	+0.558	+0.503	.002	.005	3	4
BREAST	MCEE →	-0.871	-0.368	.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	SH3PXD2A →	+2.138	+1.729	.006	<.001	3	3
SOFT_TISSUE	OSBPL11 →	+1.023	+0.234	<.001	.005	3	3
KIDNEY	NAP1L1 →	+0.942	+0.231	<.001	<.001	3	3
KIDNEY	HLA-F →	-1.877	-0.278	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046015 vs ARL14EP — BLOOD_Leukemia

Explore this scatter interactively →