Negative regulation of calcium ion-dependent exocytosis

Across TCGA patient cohorts, RNA activity of the Negative regulation of calcium ion-dependent exocytosis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PPM1B_S386, RIC1, and HDHD3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of calcium ion-dependent exocytosis activity versus PPM1B_S386 in BRCA (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PPM1B_S386 →	+1.041	+0.067	.002	.004	3	4
PDAC	RIC1 →	+0.515	+0.093	.008	.001	3	3
COAD	HDHD3 →	+0.278	+0.039	<.001	.002	3	3
CCRCC	SPINDOC_S308 →	+0.696	+0.091	<.001	<.001	3	3
OV	ZC3H13_S242 →	+0.717	+0.067	.005	.007	3	3
CCRCC	MYRF_S294 →	+0.377	+0.084	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045955 vs PPM1B_S386 — BRCA

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