Positive regulation of mitotic cell cycle

Across TCGA patient cohorts, RNA activity of the Positive regulation of mitotic cell cycle pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TOP2A_S1247, RFC2, and RRM2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mitotic cell cycle activity versus TOP2A_S1247 in LUAD (Pearson r = 0.75).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TOP2A_S1247 →	+1.402	+0.070	<.001	<.001	3	10
HNSC	RFC2 →	+0.434	+0.092	<.001	<.001	3	9
LUAD	RRM2 →	+0.934	+0.077	<.001	<.001	3	9
GBM	SMC4 →	+0.652	+0.052	<.001	<.001	3	9
CCRCC	TACC3_S71 →	+1.204	+0.062	<.001	<.001	3	9
BRCA	TFDP1_S23 →	+0.769	+0.025	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045931 vs TOP2A_S1247 — LUAD

Explore this scatter interactively →