Negative regulation of growth

Across TCGA cell cohorts, RNA activity of the Negative regulation of growth pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC43A1, NECTIN4, and PTPN6, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of growth activity versus SLC43A1 in SKIN (Pearson r = -0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SLC43A1 →	-1.762	-0.181	.001	<.001	3	7
LUNG_NSCLC_LUAD	NECTIN4 →	+2.747	+0.172	<.001	<.001	3	7
LUNG_NSCLC_LUAD	PTPN6 →	+1.761	+0.131	<.001	<.001	3	6
PANCREAS	C11orf52 →	+2.040	+0.289	.004	.001	3	6
BREAST	LY6D →	+2.732	+0.219	<.001	.001	3	6
PANCREAS	ECSIT →	-0.832	-0.303	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045926 vs SLC43A1 — SKIN

Explore this scatter interactively →