Negative regulation of growth

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of growth pathway is associated with patient survival in 18 of 34 cancer lineages. Pathway activity is summarized from the expression of its 246 member genes.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher Negative regulation of growth pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and ESCA, show the opposite pattern, with higher activity associated with better survival.

ACC, HNSC, and KIRC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.657	0.905	<.001	111	view →
HNSC	DFS	Tertile	II,III,IV	0.710	0.520	.001	101	view →
KIRC	DFS	Median	All	0.529	0.706	<.001	98	view →
MESO	OS	Median	II,III,IV	0.253	0.473	<.001	59	view →
ESCA	OS	Median	III,IV	0.636	0.313	.003	34	view →
OV	DFS	Quartile	IV	0.341	0.668	.005	22	view →
BRCA	OS	Quartile	III,IV	0.921	0.745	.001	21	view →
UCS	OS	Tertile	II,III,IV	0.545	0.204	.047	20	view →
LGG	DFS	Median	All	0.669	0.778	.004	20	view →
LAML	DFS	Tertile	All	0.410	0.649	.007	16	view →
LIHC	OS	Quartile	All	0.624	0.823	.006	12	view →
LUSC	OS	Median	III,IV	0.539	0.916	.006	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

GO:0045926–ACC (OS)

Open the ACC breakdown →