Negative regulation of DNA recombination

Across TCGA patient cohorts, RNA activity of the Negative regulation of DNA recombination pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TOP2A, TOP2A_S1247, and DHX9, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of DNA recombination activity versus TOP2A in LUAD (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TOP2A →	+0.713	+0.296	<.001	<.001	3	6
GBM	TOP2A_S1247 →	+1.052	+0.740	<.001	<.001	3	6
GBM	DHX9 →	+0.239	+0.639	<.001	<.001	3	6
GBM	RFC1 →	+0.341	+0.628	<.001	<.001	3	5
GBM	SETDB1_S1066 →	+0.932	+1.018	<.001	<.001	3	5
BRCA	SMU1 →	+0.230	+1.274	<.001	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045910 vs TOP2A — LUAD

Explore this scatter interactively →