Positive regulation of vasoconstriction

Across TCGA cell cohorts, RNA activity of the Positive regulation of vasoconstriction pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H1-9P, SMOX, and AVPR1A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, H1-9P grouped by Positive regulation of vasoconstriction-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	H1-9P →	+0.228	+1.225	.004	<.001	3	5
LUNG_NSCLC_LUAD	SMOX →	-0.150	-0.783	.002	.003	3	5
LUNG_SCLC	AVPR1A →	-0.201	-0.901	.001	.009	3	5
LUNG_NSCLC_LUSC	TRMT13 →	-0.235	-1.458	.004	<.001	3	4
LUNG_NSCLC_LUSC	ZNF181 →	+0.246	+1.504	<.001	.002	3	4
OESOPHAGUS	RILPL2 →	-0.182	-1.345	.009	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

H1-9P by Positive regulation of vasoconstriction activity — KIDNEY

Explore this box plot interactively →