Positive regulation of smoothened signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of smoothened signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FERMT3, FSTL1, and MACROH2A2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of smoothened signaling pathway activity versus FERMT3 in GBM (Pearson r = -0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FERMT3 →	-0.603	-0.067	.002	<.001	3	7
OV	FSTL1 →	+0.686	+0.049	.001	<.001	3	7
UCEC	MACROH2A2 →	+0.452	+0.053	<.001	<.001	3	7
BRCA	TP53BP1 →	+0.314	+0.034	<.001	.001	3	7
BRCA	ISG20 →	-0.768	-0.040	<.001	<.001	3	7
BRCA	CLEC11A →	+0.840	+0.032	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045880 vs FERMT3 — GBM

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