Positive regulation of smoothened signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of smoothened signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GLB1, ABCC3, and CETN2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of smoothened signaling pathway activity versus GLB1 in GBM (Pearson r = 0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GLB1 →	+0.312	+0.617	<.001	.001	3	4
LUAD	ABCC3 →	+0.968	+0.146	.001	.003	3	4
LUAD	CETN2 →	+0.425	+0.152	.001	.001	3	4
LUAD	CAPN2 →	+0.502	+0.201	<.001	<.001	3	4
LUAD	ASL →	+0.441	+0.144	<.001	.002	3	3
GBM	ANXA1 →	+0.887	+0.629	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045880 vs GLB1 — GBM

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