Positive regulation of smoothened signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of smoothened signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF250, SATB2, and GSN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF250 grouped by Positive regulation of smoothened signaling pathway-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ZNF250 →	-0.966	-0.314	.008	.005	3	5
PANCREAS	SATB2 →	-1.128	-0.202	.001	.007	3	4
SOFT_TISSUE	GSN →	+2.040	+0.213	.002	.003	3	4
STOMACH	RPL36 →	-1.109	-0.333	.003	.007	3	4
STOMACH	C17orf80 →	-0.733	-0.272	.001	.007	3	4
STOMACH	GPRIN1 →	-1.473	-0.208	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF250 by Positive regulation of smoothened signaling pathway activity — BLOOD_Lymphoma

Explore this box plot interactively →