Positive regulation of smoothened signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of smoothened signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ROR1, DCAF13, and EIF3K, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of smoothened signaling pathway activity versus ROR1 in LUNG_NSCLC_LUAD (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ROR1 →	+0.913	+0.583	.004	.004	3	4
OESOPHAGUS	DCAF13 →	-0.771	-0.883	.002	<.001	3	4
OESOPHAGUS	EIF3K →	-0.844	-0.658	.002	.005	3	4
OVARY	ANGEL1 →	+0.660	+0.836	.008	.009	3	4
CNS	IFNGR2 →	-0.783	-0.811	.003	.002	3	3
SOFT_TISSUE	KLHDC2 →	+0.627	+1.168	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045880 vs ROR1 — LUNG_NSCLC_LUAD

Explore this scatter interactively →