Positive regulation of lipid metabolic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of lipid metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SORBS1, TNS2, and TNS2_S120, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of lipid metabolic process activity versus SORBS1 in CCRCC (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SORBS1 →	+0.785	+0.045	<.001	<.001	3	10
OV	TNS2 →	+0.449	+0.028	<.001	.001	3	10
BRCA	TNS2_S120 →	+0.493	+0.023	<.001	<.001	3	10
LUAD	ATAD2_S342 →	-1.486	-0.033	<.001	<.001	3	9
BRCA	EIF5B →	-0.232	-0.032	<.001	<.001	3	9
OV	HAAO →	+0.464	+0.026	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045834 vs SORBS1 — CCRCC

Explore this scatter interactively →