Negative regulation of lipid metabolic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of lipid metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEPTIN4, COMP, and BPTF, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of lipid metabolic process activity versus SEPTIN4 in LSCC (Pearson r = 0.02).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SEPTIN4 →	+0.359	+0.027	.001	.007	3	7
COAD	COMP →	+0.884	+0.013	<.001	<.001	3	6
BRCA	BPTF →	-0.269	-0.019	<.001	<.001	3	6
LSCC	CLIC2 →	+0.526	+0.032	<.001	<.001	3	6
GBM	DAB2 →	+0.491	+0.025	<.001	<.001	3	6
BRCA	HAAO →	+0.465	+0.015	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045833 vs SEPTIN4 — LSCC

Explore this scatter interactively →