Negative regulation of lipid metabolic process

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of lipid metabolic process pathway differs between tumor and matched normal tissue in 11 of the 18 cancer types tested.

The strongest signal is observed in lung adenocarcinoma (LUAD), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as LUAD and KICH, show the opposite pattern, with lower activity in tumor tissue.

LUAD, KICH, and KIRP show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
LUAD	Male	II,III,IV	−0.040	<.001	9	view →
KICH	Male	II,III,IV	−0.034	<.001	9	view →
KIRP	All	III,IV	−0.032	<.001	9	view →
THCA	All	All	−0.012	<.001	8	view →
LUSC	Female	All	−0.042	<.001	7	view →
BRCA	All	III,IV	−0.054	<.001	6	view →
KIRC	Male	II,III,IV	−0.012	.004	5	view →
STAD	All	All	+0.025	.011	3	view →
ESCA	All	II,III,IV	+0.034	.019	2	view →
BLCA	All	IV	+0.022	.026	1	view →
LIHC	All	All	+0.008	.009	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 11 strongest of 11 lineages.

GO:0045833–LUAD

Open the LUAD breakdown →