Negative regulation of lipid metabolic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of lipid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SP5, CNPPD1, and AHNAK2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of lipid metabolic process activity versus SP5 in UCEC (Pearson r = 0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SP5 →	+1.197	+0.116	.009	.002	3	3
BRCA	CNPPD1 →	+0.295	+0.457	.003	.003	3	3
LUAD	AHNAK2 →	-0.866	-0.127	.007	.009	2	4
BRCA	MED11 →	+0.321	+0.523	.004	.002	3	3
OV	PPIAP1 →	-0.504	-0.130	.001	.005	3	3
OV	HADHAP1 →	-0.489	-0.226	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045833 vs SP5 — UCEC

Explore this scatter interactively →