Q-omics provides the consensus-scored PPIAP1 profile across patient tissues and cancer cell-line models. PPIAP1 expression is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in STAD. Among the 18 cancer types available for tumor–normal comparison, PPIAP1 is differentially expressed in 3, with the highest sampling consensus in BRCA. Additionally, PPIAP1 RNA expression shows 4,975 significant protein co-abundance associations, with the highest sampling consensus in OV. Together, these results highlight STAD, BRCA, and OV as cancer lineages where PPIAP1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for PPIAP1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes PPIAP1 survival associations across molecular data types. PPIAP1 RNA expression shows survival associations in the most cancer types (21). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible PPIAP1 RNA expression–survival associations across cancer types. High PPIAP1 expression shows unfavorable associations in STAD, BLCA, LUAD, UCEC and BRCA, but favorable associations in THCA. The STAD Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .004). Together, the overview and detailed table identify STAD as the clearest survival context for PPIAP1 RNA expression.
This table summarizes PPIAP1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 3. The strongest signals are observed in BRCA for RNA.
This table ranks reproducible tumor–normal expression differences for PPIAP1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. PPIAP1 shows higher tumor expression in BRCA, LUAD and BLCA. The BRCA box plot shows higher PPIAP1 RNA expression in tumor versus normal tissue (log2 FC = +0.030, t-test p = .004).
This table shows molecular features associated with PPIAP1 in patient tissues and cancer cell lines. In patient samples, PPIAP1 shows the broadest associations at the RNA and protein expression levels, with OV recurring as the lineage with the largest associated feature set.
