Negative regulation of DNA repair

Across TCGA patient cohorts, RNA activity of the Negative regulation of DNA repair pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VRK1, RACGAP1, and RFC2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of DNA repair activity versus VRK1 in GBM (Pearson r = 0.52).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	VRK1 →	+0.412	+0.040	<.001	<.001	3	9
LUAD	RACGAP1 →	+0.910	+0.063	<.001	<.001	3	9
LSCC	RFC2 →	+0.416	+0.051	<.001	<.001	3	9
LUAD	SMC4 →	+0.741	+0.072	<.001	<.001	3	9
UCEC	TPX2 →	+1.027	+0.067	<.001	<.001	3	9
LSCC	FEN1 →	+0.507	+0.058	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045738 vs VRK1 — GBM

Explore this scatter interactively →