Negative regulation of DNA repair

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of DNA repair pathway differs between tumor and matched normal tissue in 15 of the 18 cancer types tested.

The strongest signal is observed in colon adenocarcinoma (COAD), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as PAAD, show the opposite pattern, with lower activity in tumor tissue.

COAD, HNSC, and LIHC show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
COAD	Female	III,IV	+0.058	<.001	11	view →
HNSC	Male	All	+0.037	<.001	11	view →
LIHC	Female	II,III,IV	+0.041	<.001	9	view →
LUSC	Male	II,III,IV	+0.064	<.001	8	view →
STAD	All	II,III,IV	+0.051	<.001	6	view →
BLCA	All	All	+0.045	<.001	6	view →
BRCA	All	II,III,IV	+0.039	<.001	6	view →
LUAD	Male	II,III,IV	+0.036	<.001	6	view →
UCEC	All	All	+0.033	.008	4	view →
KICH	All	All	+0.022	.004	4	view →
READ	All	All	+0.063	<.001	3	view →
CHOL	Male	All	+0.063	<.001	2	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 15 lineages.

GO:0045738–COAD

Open the COAD breakdown →