Negative regulation of gluconeogenesis

Across TCGA cell cohorts, RNA activity of the Negative regulation of gluconeogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MLST8, BCL6, and UQCRC2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of gluconeogenesis activity versus MLST8 in LUNG_SCLC (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MLST8 →	+0.604	+0.637	<.001	.005	3	5
LUNG_SCLC	BCL6 →	-2.068	-0.579	.001	.004	3	4
LUNG_SCLC	UQCRC2 →	+0.518	+0.465	.002	.005	3	4
BLOOD_Leukemia	H2BC4 →	+1.217	+0.179	.007	.009	3	3
STOMACH	ST3GAL1 →	-3.482	-0.430	.006	.007	3	3
SKIN	NDUFS1 →	+0.432	+0.284	.008	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045721 vs MLST8 — LUNG_SCLC

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