Regulation of epidermis development

Across TCGA cell cohorts, RNA activity of the Regulation of epidermis development pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SH3BP2, TRIM16, and TFAP4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SH3BP2 grouped by Regulation of epidermis development-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	SH3BP2 →	+1.861	+0.260	.002	.007	2	5
OVARY	TRIM16 →	-1.188	-0.647	.008	.004	3	3
STOMACH	TFAP4 →	+0.914	+0.221	.003	.007	3	3
BONE	PRMT5 →	+1.052	+1.945	.003	<.001	3	3
BONE	LRP1 →	-1.769	-1.560	.008	.003	3	3
LARGE_INTESTINE	CD83 →	+1.322	+0.180	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SH3BP2 by Regulation of epidermis development activity — LIVER

Explore this box plot interactively →