Positive regulation of osteoclast differentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of osteoclast differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RELB, MSR1, and CDC42EP1_S353, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of osteoclast differentiation activity versus RELB in OV (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RELB →	+0.270	+0.044	<.001	.003	3	6
UCEC	MSR1 →	+0.406	+0.052	.003	.005	3	6
OV	CDC42EP1_S353 →	+0.701	+0.045	.001	<.001	2	6
OV	TYMP →	+0.557	+0.042	.003	.005	2	6
OV	FGD6_S1197 →	+1.052	+0.053	<.001	.002	3	5
LSCC	TBC1D9B →	+0.205	+0.067	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045672 vs RELB — OV

Explore this scatter interactively →