Positive regulation of osteoclast differentiation

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation of osteoclast differentiation pathway differs between tumor and matched normal tissue in 11 of the 18 cancer types tested.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as LUSC and LUAD, show the opposite pattern, with lower activity in tumor tissue.

LUSC, LUAD, and KIRC show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
LUSC	Female	All	−0.077	<.001	7	view →
LUAD	Female	All	−0.038	<.001	6	view →
KIRC	All	II,III,IV	+0.026	.002	6	view →
HNSC	All	All	+0.017	.003	6	view →
BLCA	Male	All	−0.052	<.001	4	view →
THCA	All	All	−0.019	.003	4	view →
BRCA	All	All	−0.015	.001	4	view →
COAD	Male	II,III,IV	+0.024	.021	3	view →
PAAD	Female	All	+0.054	.038	2	view →
KIRP	All	All	+0.027	.011	2	view →
KICH	Female	All	−0.029	.029	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 11 strongest of 11 lineages.

GO:0045672–LUSC

Open the LUSC breakdown →