Positive regulation of osteoclast differentiation

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation of osteoclast differentiation pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 27 member genes.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher Positive regulation of osteoclast differentiation pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SKCM and KIRP, show the opposite pattern, with higher activity associated with better survival.

BLCA, LGG, and SKCM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Tertile	All	0.551	0.690	.003	47	view →
LGG	DFS	Median	All	0.322	0.473	<.001	42	view →
SKCM	DFS	Median	All	0.687	0.572	.001	26	view →
KIRP	OS	Median	All	0.912	0.646	.025	18	view →
LUSC	OS	Tertile	III,IV	0.331	0.862	.008	17	view →
ACC	OS	Median	II,III,IV	0.641	0.837	.020	16	view →
UCS	DFS	Tertile	IV	0.942	0.399	.017	12	view →
KIRC	DFS	Quartile	All	0.903	0.720	.001	12	view →
SCLC	DFS	Quartile	II,III,IV	0.301	0.630	.016	12	view →
READ	OS	Tertile	II,III,IV	0.805	0.342	.009	10	view →
COAD	OS	Quartile	IV	1.000	0.248	.005	9	view →
CHOL	DFS	Median	II,III,IV	0.806	0.135	.009	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0045672–BLCA (DFS)

Open the BLCA breakdown →