Positive regulation of osteoclast differentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of osteoclast differentiation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TUB, NPAS2, and MAPT-AS1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of osteoclast differentiation activity versus TUB in CCRCC (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TUB →	-0.944	-0.419	<.001	.007	3	2
CCRCC	NPAS2 →	+0.425	+0.441	.006	.003	3	2
CCRCC	MAPT-AS1 →	-0.361	-0.468	.002	.005	3	2
GBM	ARL15 →	-0.349	-0.347	.004	.004	3	2
GBM	MIR581 →	-0.534	-0.309	<.001	.005	3	2
GBM	UBE2SP2 →	-0.415	-0.385	.005	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045672 vs TUB — CCRCC

Explore this scatter interactively →