Positive regulation of osteoclast differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of osteoclast differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BPNT2, VCPIP1, and YTHDF3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BPNT2 grouped by Positive regulation of osteoclast differentiation-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	BPNT2 →	+1.251	+1.693	<.001	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	VCPIP1 →	+0.895	+0.235	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	YTHDF3 →	+0.923	+0.198	.002	<.001	3	5
LARGE_INTESTINE	OSGIN2 →	+0.687	+1.080	<.001	<.001	3	5
BLOOD_Lymphoma	LPIN2 →	+2.916	+2.221	.002	<.001	3	4
BLOOD_Lymphoma	SPRING1 →	+1.182	+1.989	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BPNT2 by Positive regulation of osteoclast differentiation activity — BONE

Explore this box plot interactively →