Positive regulation of osteoclast differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of osteoclast differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP3CA, CEP97, and CEP72, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of osteoclast differentiation activity versus PPP3CA in BONE (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	PPP3CA →	+1.219	+0.300	<.001	.004	3	3
BONE	CEP97 →	+0.597	+0.282	.003	<.001	3	3
BREAST	CEP72 →	+1.075	+0.975	.008	.002	3	3
BREAST	FN1 →	+3.288	+0.908	.002	.008	2	4
BREAST	KLHL29 →	+1.144	+0.801	.003	.005	3	3
BREAST	CIT →	+0.679	+0.709	.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045672 vs PPP3CA — BONE

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