Negative regulation of T-helper 2 cell differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of T-helper 2 cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLI, KIR2DL4, and CHD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, POLI grouped by Negative regulation of T-helper 2 cell differentiation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	POLI →	+0.230	+0.506	<.001	<.001	3	4
OVARY	KIR2DL4 →	-0.197	-0.101	.005	.001	3	4
KIDNEY	CHD1 →	+0.262	+0.080	.002	.006	3	4
OESOPHAGUS	DCAF5 →	-0.121	-0.081	.008	.002	3	4
LUNG_NSCLC_LUAD	STARD9 →	-0.224	-0.146	.007	.003	2	5
LARGE_INTESTINE	PRIM1 →	+0.210	+0.148	.009	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

POLI by Negative regulation of T-helper 2 cell differentiation activity — BREAST

Explore this box plot interactively →