Regulation of T-helper 2 cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of T-helper 2 cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RHBDD3, RNMT, and LOXL4, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of T-helper 2 cell differentiation activity versus RHBDD3 in LARGE_INTESTINE (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RHBDD3 →	+0.674	+0.321	.009	.006	2	1
LARGE_INTESTINE	RNMT →	+0.693	+0.289	.009	<.001	2	1
LARGE_INTESTINE	LOXL4 →	+1.470	+0.303	.004	.001	2	1
LARGE_INTESTINE	ANKRD40 →	+0.473	+0.289	.004	<.001	2	1
LARGE_INTESTINE	TBC1D8 →	+0.826	+0.289	.005	<.001	2	1
LARGE_INTESTINE	POF1B →	-2.840	-0.326	.008	.004	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045628 vs RHBDD3 — LARGE_INTESTINE

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