Negative regulation of B cell differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of B cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are C1R, CRTAP, and C1S, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of B cell differentiation activity versus C1R in BRCA (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	C1R →	+0.580	+0.072	<.001	<.001	3	9
LUAD	CRTAP →	+0.511	+0.129	<.001	<.001	3	9
BRCA	C1S →	+0.649	+0.077	<.001	<.001	3	8
OV	COL5A1 →	+0.929	+0.106	<.001	<.001	3	8
OV	SEC23A →	+0.324	+0.080	<.001	<.001	3	8
UCEC	LGALS1 →	+0.634	+0.091	<.001	.003	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045578 vs C1R — BRCA

Explore this scatter interactively →