Negative regulation of B cell differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of B cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OTUB1, NPAS3, and GLCCI1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OTUB1 grouped by Negative regulation of B cell differentiation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OTUB1 →	-0.777	-0.781	.004	.006	3	4
CNS	NPAS3 →	-0.671	-0.795	.003	<.001	3	3
KIDNEY	GLCCI1 →	+1.428	+1.583	<.001	<.001	3	3
KIDNEY	SDK1 →	+1.246	+0.991	.005	.004	3	3
KIDNEY	CDC123 →	-0.668	-1.566	.005	<.001	3	3
BLOOD_Lymphoma	SAAL1 →	-0.865	-1.584	.007	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OTUB1 by Negative regulation of B cell differentiation activity — BREAST

Explore this box plot interactively →