Negative regulation of B cell differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of B cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ID2, AHNAK2, and CLIP4, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of B cell differentiation activity versus ID2 in BLOOD_Myeloma (Pearson r = 0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	ID2 →	+3.603	+1.191	<.001	.005	3	20
LIVER	AHNAK2 →	-4.090	-0.330	<.001	.003	3	8
BREAST	CLIP4 →	-2.377	-0.575	<.001	.003	3	7
OVARY	FSTL1 →	-2.598	-0.539	.006	.006	3	7
BONE	SAMD4A →	-2.089	-0.225	<.001	.002	3	7
BONE	TNFRSF12A →	-3.485	-0.227	<.001	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045578 vs ID2 — BLOOD_Myeloma

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