Negative regulation of MHC class II biosynthetic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of MHC class II biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NCL_T121, SFPQ, and BLVRB, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of MHC class II biosynthetic process activity versus NCL_T121 in LUAD (Pearson r = -0.04).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	NCL_T121 →	+1.003	+0.058	<.001	<.001	3	6
LUAD	SFPQ →	+0.105	+0.045	<.001	<.001	3	5
GBM	BLVRB →	-0.515	-0.058	<.001	<.001	3	5
CCRCC	TRAFD1 →	+0.343	+0.061	.001	<.001	3	5
LUAD	NCL_T76 →	+1.056	+0.045	<.001	<.001	3	5
CCRCC	SLC4A1_S357 →	-1.807	-0.070	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045347 vs NCL_T121 — LUAD

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