Negative regulation of MHC class II biosynthetic process

pathway activity — tumor vs normal
GO:0045347Tumor vs NormalRNA activityBox plot · TCGA cohorts

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of MHC class II biosynthetic process pathway differs between tumor and matched normal tissue in 11 of the 18 cancer types tested.

The strongest signal is observed in thyroid carcinoma (THCA), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors.

THCA, COAD, and LIHC show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log2 scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.
LineageGenderStageActivity changepSampling consensus
THCAAllIV+0.157<.00111view →
COADAllIII,IV+0.083<.0019view →
LIHCMaleAll+0.069<.0018view →
LUSCFemaleAll+0.086<.0016view →
KIRPMaleII,III,IV+0.075.0056view →
LUADAllAll+0.042<.0015view →
BRCAAllII,III,IV+0.042<.0014view →
KIRCFemaleAll+0.053.0033view →
CHOLAllAll+0.081.0092view →
STADAllAll+0.045.0152view →
HNSCMaleIV+0.070.0061view →
Pink = more active in tumor, green = less active in tumor. Showing the 11 strongest of 11 lineages.

GO:0045347–THCA

Tumor-vs-normal pathway-activity box plot for Negative regulation of MHC class II biosynthetic process in THCA.

Open the THCA breakdown →

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