Negative regulation of MHC class II biosynthetic process

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of MHC class II biosynthetic process pathway is associated with patient survival in 27 of 34 cancer lineages. Pathway activity is summarized from the expression of its 6 member genes.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher Negative regulation of MHC class II biosynthetic process pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SKCM and UVM, show the opposite pattern, with higher activity associated with better survival.

LIHC, SKCM, and UVM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	DFS	Tertile	III,IV	0.160	0.436	<.001	98	view →
SKCM	OS	Tertile	III,IV	0.763	0.576	.003	40	view →
UVM	DFS	Tertile	All	1.000	0.459	<.001	29	view →
COAD	OS	Median	III,IV	0.851	0.719	.005	27	view →
GBM	DFS	Median	All	0.401	0.176	<.001	27	view →
LGG	OS	Quartile	All	0.938	0.810	<.001	26	view →
ESCA	OS	Tertile	All	0.591	0.774	.007	24	view →
CESC	DFS	Median	All	0.806	0.686	.015	22	view →
DLBC	OS	Median	II,III,IV	0.340	1.000	.006	18	view →
THYM	OS	Median	II,III,IV	0.960	0.695	.003	15	view →
ACC	DFS	Tertile	All	0.770	0.347	.007	14	view →
KIRP	OS	Tertile	All	0.873	0.970	.003	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

GO:0045347–LIHC (DFS)

Open the LIHC breakdown →