Clustering of voltage-gated sodium channels

Across TCGA patient cohorts, RNA activity of the Clustering of voltage-gated sodium channels pathway is significantly associated with the RNA expression of multiple genes, with the ESCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LY86, NRCAM, and AGRN, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Clustering of voltage-gated sodium channels activity versus LY86 in ESCA (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	LY86 →	-0.749	-0.056	.001	.005	2	18
TGCT	NRCAM →	+2.541	+0.114	<.001	<.001	3	17
LAML	AGRN →	+1.214	+0.111	<.001	<.001	3	17
SARC	DCN →	-1.828	-0.037	<.001	<.001	3	16
SARC	LSP1 →	-1.264	-0.038	<.001	<.001	3	16
SARC	BTK →	-1.070	-0.042	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045162 vs LY86 — ESCA

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