Clustering of voltage-gated sodium channels

Across TCGA pan-cancer cohorts, RNA activity of the Clustering of voltage-gated sodium channels pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 6 member genes.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher Clustering of voltage-gated sodium channels pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as MESO and KIRC, show the opposite pattern, with higher activity associated with better survival.

SKCM, DLBC, and MESO are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Tertile	All	0.520	0.683	<.001	85	view →
DLBC	DFS	Tertile	II,III,IV	0.571	1.000	.002	31	view →
MESO	OS	Quartile	All	0.512	0.317	.013	29	view →
KIRC	DFS	Median	II,III,IV	0.844	0.727	.006	25	view →
LUSC	DFS	Median	All	0.465	0.319	.010	21	view →
LGG	DFS	Median	All	0.651	0.795	.003	20	view →
COAD	OS	Quartile	IV	0.375	0.853	.002	19	view →
STAD	DFS	Median	IV	0.134	0.503	.001	18	view →
LAML	DFS	Tertile	All	0.726	0.471	.027	14	view →
BLCA	DFS	Tertile	IV	0.362	0.113	.020	9	view →
PCPG	DFS	Quartile	All	1.000	0.674	.032	6	view →
KIRP	DFS	Quartile	IV	0.042	0.291	.017	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:0045162–SKCM (DFS)

Open the SKCM breakdown →