Clustering of voltage-gated sodium channels

Across TCGA patient cohorts, RNA activity of the Clustering of voltage-gated sodium channels pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSDC2, TMCC2-AS1, and ANKRD65, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Clustering of voltage-gated sodium channels activity versus CSDC2 in BRCA (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CSDC2 →	+0.701	+0.652	.002	.007	3	3
CCRCC	TMCC2-AS1 →	+0.160	+0.507	.002	.005	3	3
OV	ANKRD65 →	+0.973	+0.421	.006	.007	3	3
LSCC	APOL4 →	+0.713	+0.525	.006	.003	3	3
LSCC	KCNQ5 →	+0.703	+0.595	.005	<.001	3	3
LUAD	TNK1 →	+0.278	+0.472	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045162 vs CSDC2 — BRCA

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